Figure 3. Screening of copolymer hydrogels to select top immune-resistant materials for further evaluation.

a. Polyacrylamide copolymer hydrogels were implanted in the subcutaneous space of mice for 28 days, upon which the tissues and gels were removed to examine foreign body response. b. Representative sections of tissue and subsequent MT and H&E Staining. Scale bar represents 100 μm unless otherwise specified. c. Fibrous capsule thickness of n = 3 samples (mean ± s.d.) where each mean was determined from the median of 10 thicknesses per image. d. Inflammation score determined by pathologists blinded to the test materials to characterize extent of inflammation.