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. Author manuscript; available in PMC: 2024 Jul 1.
Published in final edited form as: J Biomed Mater Res A. 2023 Mar 2;111(7):910–920. doi: 10.1002/jbm.a.37521

Figure 5. Application of leading hydrogel coating to osmotic insulin pumps.

Figure 5.

a. Osmotic pumps with bare silicone tips (black) and D5-coated tips (blue) on implantable osmotic pumps. b. Schematic of experimental timeline, whereby pumps were implanted in the dorsal region of diabetic rats, blood was collected over the course of 28 days, and pumps and tissues were explanted at the end of the study. c. After 28 days, hydrogel coated pumps appear to have noticeably less fibrosis and protein aggregation. d. Blood insulin values over time, determined by ELISA. e. Pump survival curve demonstrating the timeframe over which pumps remain functional and consistently deliver insulin. Statistical significance of pump survival assessed with a Mantel-Cox test. f. Immunostaining and histopathology of excised tissue and catheter tips. Scale bar represents 500 μm.