Table 5.
COX univariate analysis
| Factor | Group | Recurrence rate (%) | p-value | HR (95% CI) |
|---|---|---|---|---|
| Age, years | ≥65 | 50.0 | 0.424 | 0.765 (0.392–1.492） |
| ＜65 | 46.5 | |||
| BMI, kg/m2 | ≥28 | 56.3 | 0.550 | 0.806 (0.392–1.656） |
| ＜28 | 45.7 | |||
| Gender | Male | 51.9 | 0.158 | 0.615 (0.308–1.227） |
| Female | 34.5 | |||
| Number of lesions | Multiple | 82.6 | 0.000 | 0.320 (0.180–0.569） |
| Single | 37.6 | |||
| Maximum diameter of lesions, mm | ≥20 | 46.1 | 0.561 | 1.224 (0.613–2.444） |
| ＜20 | 52.6 | |||
| Liver cirrhosis history | Yes | 49.0 | 0.299 | 0.590 (0.212–1.638） |
| No | 33.3 | |||
| Drinking history | Yes | 61.9 | 0.106 | 0.602 (0.321–1.131） |
| No | 43.7 | |||
| AFP, ng/ml | ≥400 | 70.6 | 0.043 | 0.523 (0.274–1.000） |
| ＜400 | 42.9 | |||
| Child-pugh grades | A | 48.0 | 0.534 | 0.696 (0.217–2.235） |
| B | 37.5 | |||
| ALT, U/L | ≥40 | 46.9 | 0.972 | 0.989 (0.542–1.807） |
| ＜40 | 47.4 | |||
| AST, U/L | ≥40 | 44.4 | 0.976 | 1.010 (0.529–1.930） |
| ＜40 | 48.1 | |||
| TBIL, μmol/L | ≥34 | 66.7 | 0.383 | 0.542 (0.132–2.234） |
| ＜34 | 46.7 | |||
| ALB, G/L | ≥35 | 48.3 | 0.485 | 0.777 (0.378–1.597） |
| ＜35 | 42.9 | |||
| Pre-operative leukocytes, x109/L | ≥5.575 | 55.6 | 0.205 | 0.699 (0.398–1.228） |
| ＜5.575 | 43.1 | |||
| Post-operative leukocytes, x109/L | ≥6.61 | 60.7 | 0.004 | 0.438 (0.244–0.787） |
| ＜6.61 | 32.7 | |||
| Pre-operative lymphocytes, x109/L | ≥1.455 | 49.2 | 0.669 | 0.886 (0.505–1.555） |
| ＜1.455 | 44.4 | |||
| Post-operative lymphocytes, x109/L | ≥1.025 | 30.0 | 0.000 | 3.138 (1.758–5.602） |
| ＜1.025 | 68.8 | |||
| Pre-operative neutrophils, x109/L | ≥3.431 | 72.7 | 0.000 | 0.366 (0.210–0.637） |
| ＜3.431 | 36.0 | |||
| Post-operative neutrophils cells, x109/L | ≥4.975 | 74.5 | 0.000 | 0.250 (0.137–0.457） |
| ＜4.975 | 26.2 | |||
| Pre-operative NLR | ≥1.53 | 63.9 | 0.000 | 0.289 (0.151–0.555） |
| ＜1.53 | 25.5 | |||
| Post-operative NLR | ≥4.36 | 75.0 | 0.000 | 0.183 (0.095–0.352） |
| ＜4.36 | 21.4 | |||
| PP-NLR | 0 | 19.4 | 0.000 | 3.091 (2.045–4.672） |
| 1 | 32.3 | |||
| 2 | 82.9 |
AFP, alpha-fetoprotein; ALB, albumin; ALT, alanine transaminase; AST, aspartate transaminase; BMI, body mass index; CI, confidence interval; HR, hazard ratio; NLR, neutrophil to lymphocyte ratio; PP-NLR, pre-operative combined post-operative neutrophil to lymphocyte ratio; TBIL, total bilirubin.
Notes：The data are presented as hazard ratio (confidence interval 95%). p-values using the Log-rank test.