Table 4.
Drug-likeness of the tested compounds (Lipinski’s rule of five).
| Compound no. | Properties | Comment |
|---|---|---|
| 9 |
Log P = 0.21 (< 5) Molecular weight = 170.12 g/mol (< 500) No of H-bond donor groups (OHs + NHs) = 4 (≤ 5) No of H-bond acceptor atoms (Os + Ns) = 5 (≤ 10) |
No violation |
| 16 |
Log P = 1.52 (< 5) Molecular weight = 360.31 g/mol (< 500) No of H-bond donor groups (OHs + NHs) = 5 (≤ 5) No of H-bond acceptor atoms (Os + Ns) = 8 (≤ 10) |
No violation |
| 17 |
Log P = -0.48 (< 5) Molecular weight = 636.47 g/mol (> 500) No of H-bond donor groups (OHs + NHs) = 11 (> 5) No of H-bond acceptor atoms (Os + Ns) = 18 (> 10) |
Three violations |
| 20 |
Log P = − 1.07 (< 5) Molecular weight = 315.25 g/mol (< 500) No of H-bond donor groups (OHs + NHs) = 6 (> 5) No of H-bond acceptor atoms (Os + Ns) = 9 (≤ 10) |
One violation |
| 21 |
Log P = − 0.91 (< 5) Molecular weight = 300.26 g/mol (< 500) No of H-bond donor groups (OHs + NHs) = 5 (≤ 5) No of H-bond acceptor atoms (Os + Ns) = 8 (≤ 10) |
No violation |
| 22 |
Log P = − 0.81 (< 5) Molecular weight = 314.29 g/mol (< 500) No of H-bond donor groups (OHs + NHs) = 4 (≤ 5) No of H-bond acceptor atoms (Os + Ns) = 8 (≤ 10) |
No violation |
| 26 |
Log P = 3.82 (< 5) Molecular weight = 332.43 g/mol (< 500) No of H-bond donor groups (OHs + NHs) = 3 (≤ 5) No of H-bond acceptor atoms (Os + Ns) = 4 (≤ 10) |
No violation |