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. 2023 Apr 21;14:1164067. doi: 10.3389/fendo.2023.1164067

Table 1.

Pharmacodynamic/pharmacokinetic parameters of PARP inhibitors in solid tumors.

Drug Cmax (ng/mL)(25) AUC (ng/mL·h)(25) Mean T1/2 (h)(25) PARP-1 Inhibition
IC50 (nM)(24)		 PARP Inhibition
IC50* (nM) in PC(18)
Olaparib 5700~9500 33300~62100 6.52~11.9 1.94 18
Niraparib 1399~2071 19540~27852 36.2~36.45 / /
Rucaparib 1940~2650 16900~47507 12.6 1.98 18
Talazoparib 16.4~32.84 208~244 50.0~50.73 0.57 11

* PARP inhibition in DU145 PC cell line.