Figure 5.

Single-cell RNA-Seq of human RPE–choroid tissues of an intermediate AMD patient and unaffected subject. (A) and (C) Integrated UMAP of macular and peripheral single-cell RNA-Seq of intermediated AMD patient (A) and unaffected subject (C) revealing the presence of 17 cell clusters; (B) and (D) Differential expression of macular versus peripheral pericytes, and RPE cells in the intermediate AMD patient (B) and unaffected subject (D). For each gene, the average log fold change is shown on the x axis. Genes enriched in the peripheral region and macular region are shown in red and green colour, respectively.