Table 6.

Diagnostic Performances of GPC3, VEGF and GP73 in the Studied Groups after Combination

		Sn.	Sp.	PPT	NPV	Accuracy	AUC	95% C.I	P value
Double markers
Cirrhosis Vs Control	GPC3 + VEGF	60	100	100	50.0	60	0.807	0.731 - 0.868	<0.0001**
	GPC3 + GP73	78	60	83	52.2	38	0.641	0.556 - 0.721	0.0066**
	VEGF + GP73	85	80	91.4	68.1	65	0.843	0.772 - 0.899	<0.0001**
HCC Vs Cirrhosis	GPC3 + VEGF	24	89	68.6	53.9	13	0.525	0.453 - 0.596	0.5466
	GPC3 + GP73	58	60	59.2	58.8	18	0.56	0.488 - 0.630	0.1416
	VEGF + GP73	72	55	61.5	66.3	27	0.597	0.526 - 0.666	0.0163*
Triple markers
Cirrhosis Vs Control		83.33	60	83.9	59.0	43.33	0.742	0.677 to 0.799	<0.0001**
HCC Vs Cirrhosis		70.67	43.33	55.5	59.6	14	0.548	0.490 to 0.605	0.1478

Sn, Sensitivity; Sp, Specificity; PPT, Positive predictive value; NPV, Negative predictive value; AUC, Area under curve and C.I, 95% Confidence Interval.; * P value <0.05 is significant, ** P value <0.01 is highly significant