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. 2023 May 5;10(4):e200116. doi: 10.1212/NXI.0000000000200116

Figure 2. Whole-Transcriptome Analysis With RNA-Seq of TSM15 Cells After Exposure to IgG From Patients With Jo-1, SRP, or PM.

Figure 2

TSM15 cells were incubated with IgGs from patients with Jo-1 (n = 3), patients with SRP (n = 3), patients with PM (n = 3), and healthy controls (n = 3). TSM15 cells without exposure to IgGs were also used as a control. (A, B) In the network analysis of the upregulated genes, TNF-α and mitochondria complex were detected in the center of the network analysis in the Jo-1 group. (C) In the network analysis of the upregulated genes, nuclear factor-κB was detected in the center of the network in the SRP group. (D) In the network analysis of the upregulated genes, TREM-1 and ILR2A (CD25) were observed as upstream molecules of signaling in the PM group. PM = polymyositis; SRP = signal recognition particle.