TABLE 3.
Performance of Agile 4 versus LSM in identifying cirrhosis
| LSM | Agile 4 | |
|---|---|---|
| AUROC (95% CI) | 0.83 (0.78; 0.87) | 0.85 (0.81; 0.88) |
| Delong test p (vs. Agile 4) | 0.065 | NA |
| Rule out cutoff (Sen 90%) | <8 | <0.251 |
| Percentage of patients | 24 | 57 |
| Se | 0.94 (0.901; 0.979) | 0.83 (0.769; 0.891) |
| Sp | 0.30 (0.255; 0.345) | 0.71 (0.666; 0.754) |
| NPV | 0.93 (0.886; 0.974) | 0.92 (0.890; 0.950) |
| LR− | 0.21 | 0.24 |
| Gray zone | ||
| Percentage of patients (p-value vs. Agile 4) | 38 (p<0.001) | 23 |
| Rule in cutoff (Spec 90%) | >14 | ≥0.565 |
| Percentage of patients | 38 | 20 |
| Se | 0.77 (0.701; 0.839) | 0.54 (0.459; 0.621) |
| Sp | 0.76 (0.718; 0.802) | 0.93 (0.905; 0.955) |
| PPV | 0.54 (0.472; 0.608) | 0.72 (0.635; 0.805) |
| LR+ | 3.24 | 7.29 |
Abbreviations: AUROC, area under the receiver operator curve; FIB-4, fibrosis-4 index; LR+, positive likelihood ratio; LR−, negative likelihood ratio; LSM, liver stiffness measurement; NPV, negative predictive value; PPV, positive predictive value; Se, sensitivity; Sp, specificity; VCTE, vibration-controlled transient elastography.