Table 1.
Datasets Used for Assessing the Prognostic Value of IKZF1 Deletions in ETV6::RUNX1 and High Hyperdiploid Acute Lymphoblastic Leukemia
| Dataset | Genetic Subtype | IKZF1 Status | Inclusion Criteria From Original Study | |||
|---|---|---|---|---|---|---|
| Deleted | Wild-type | |||||
| n | n | Time Period | Trials/Protocols | |||
| A | ETV6::RUNX1 | 26 | 913 | Availability of MLPA data | 1991–2015 | BFM-ALL 2000, IC-BFM ALL 2002/2009, ANZCHOG ALL8, DCOG ALL8/9/10, NOPHO ALL-92/2000/2008, UKALL2003, MB-ALL-2002/2008, GBTLI LLA-2009, JACLS-ALL02, Other |
| B | High hyperdiploid | 85 | 883 | Availability of MLPA data | ||
| C | High hyperdiploid | 34 | 299 | EOI MRD >0% and <5% | 2003–2014 | CoALL07-03, DCOG ALL10, NOPHO ALL2008, UKALL2003 |
| D | High hyperdiploid | 29 | 276 | Participation in clinical trial | 2003–2013 | DCOG ALL10, UKALL2003 |
EOI MRD = end of induction minimal residual disease; MLPA = multiplex ligation-dependent probe amplification.