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. 2023 Mar 22;42(19):1524–1542. doi: 10.1038/s41388-023-02662-1

Fig. 3. Identification of the bladder enhancer repertoire and subtype specificities.

Fig. 3

A PCA of H3K27ac signal inside ROSE consensus SE (n = 2887) for all samples. B Representative examples of H3K27ac signal in Ba/Sq, Stroma-Rich, Luminal and NMIBC Tumours with corresponding RNA-seq gene expression. Orange boxes represent SE localisation. C Fold Change plots for differentially bound SEs between Ba/Sq and Luminal samples. Significance by p-value < 0.05. D Plot comparing expression LogFC between Ba/Sq and Luminal samples for genes assigned to subgroup-enriched SE. E Reactome pathway enrichment analysis of genes associated with Ba/Sq vs Luminal SEs. F Venn diagram comparing 3 differential analyses of SE. NHU-enriched SEs are enriched in NHU vs Luminal or NHU vs Basal (pink circle). Basal-enriched SEs are enriched in Basal vs NHU or Basal vs Luminal (red circle). Luminal-enriched SEs are enriched in Luminal vs NHU or Luminal vs Basal (green circle).