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. 2023 Mar 22;42(19):1524–1542. doi: 10.1038/s41388-023-02662-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A Cistrome analysis of LumP and Ba/Sq specific enhancers. B Homer motif enrichment analysis in H3K27ac differential peaks inside differential SE in Luminal vs Basal and Basal vs Luminal. C Methodology to identify key coregulated SE-associated TFs. D Heatmap of the top 75 TFs with high regulon score. Clustering identified 3 major clusters. E Heatmap of the top 75 TFs expression in TCGA-BLCA. F Correlation network of the top 55 TFs with an expression correlation coefficient of min 0.5 in TCGA-BLCA cohort. G Single-cell RNA-seq analysis of one bladder cancer tumour with both basal and luminal population (GSM4307111 [36]) Right panel, associated expression for key TFs in each compartment.