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. 2023 May 5;13:7317. doi: 10.1038/s41598-023-34404-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Case 2 MRI Brain and MRI Chest. MRI Brain: Post-contrast MRI of patient with metastatic chordoma in dura of brain (A-axial, B-coronal) and on T2/FLAIR (C) showing the lesion before starting pemetrexed 900 mg/m² and 6 weeks post-treatment in brain (D-axial, E-coronal) and on T2/FLAIR (F) showing response. CT Chest: Post-contrast Chest CT of patient with metastatic chordoma to lung and soft tissue of axilla (G-coronal, J-sagittal) showing the large lesion filling most of right lung before starting pemetrexed 900 mg/m², 6 weeks post-treatment (H-coronal, K-sagittal) showing shrinkage of tumor, and 2 years later on pemetrexed showing continued shrinkage of tumor and expansion of air ways in right lung and reduced mass effect and shift of mediastinal contents (I-coronal, L-sagittal).