Fig. 1.

(a) Overview of significant genetic associations with plasma protein and IgG N-glycan proportions in individuals with recent-onset type 1 diabetes. Genes are shown grouped with their associated glycans. Glycans are shown as per GlycoWorkBench standard figures [59]. Glycans that showed novel genetic associations are indicated by a star and presented in colour. The red dotted circles indicate glycan residues that were synthesised by the action of the enzymes encoded by the associated genes. (b) Effect of the C3 missense variant rs1047286. This SNP results in a cyclic to acyclic amino acid substitution, and is associated with altered proportions of the oligomannose plasma protein glycan