Table 2.

Adverse events

Adverse event,n(%)	Grade 1	Grade 2	Grade 3	Grade 4
Abdominal pain	1 (6)	4 (24)	0	0
Anorexia	2 (12)	5 (29)	0	0
Bronchial infection	0	3 (18)	0	0
Bruising	2 (12)	0	0	0
Constipation	2 (12)	1 (6)	0	0
Cough	2 (12)	0	1 (6)	0
Creatinine increase	1 (6)	1 (6)	0	0
Depression	0	2 (12)	0	0
Diarrhea	8 (47)	4 (24)	1(6)	0
Dizziness	1 (6)	1 (6)	0	0
Dry mouth	3 (18)	1 (6)	0	0
Dry skin	3 (18)	1 (6)	0	0
Dysgeusia	2 (12)	0	0	0
Dyspepsia	1 (6)	1 (6)	0	0
Dyspnea	1 (6)	5 (29)	0	0
Edema (limbs)	2 (12)	0	0	0
Epistaxis	2 (12)	0	0	0
Fall	1 (6)	2 (12)	0	0
Fatigue	5 (29)	4 (23)	0	0
Flank pain	2 (12)	0	0	0
Post-nasal drip	2 (12)	0	0	0
Productive cough	2 (12)	1 (6)	1 (6)	0
QT interval prolonged	0	0	2 (12)	0
Rash acneiform	4 (23)	0	0	0
Rash maculopapular	4 (23)	0	0	0
Thromboembolic event	0	0	2 (12)	1 (6)
Tumor pain	1 (6)	1 (6)	0	0
Urinary tract infection	0	2 (12)	0	0
Vomiting	2 (12)	3 (18)	0	0
Weight loss	5 (29)	1 (6)	1 (6)	0