Fig. 9. Activity of dorsal CA1 neurons discriminates non-social odors.
a Task schematic. b Training time courses. Black circles, the first session above the criterion (dashed line). c Distribution of d’ for all neurons in an example mouse. Neurons with a significant d’ are color-coded. d Proportion of odor -selective neurons (mean ± SEM, two-sided Wilcoxon signed-rank test, p = 5.8 × 10−4, n = 7 mice). e Odor identity decoding (mean ± SEM (shades), n = 7 mice). The upper bars, the period of significant decoding (Cluster-based permutation test, two-sided, p < 0.05). f A higher decoding accuracy in no-reward category (mean ± SEM, two-sided Wilcoxon signed-rank test, p = 0.025, n = 7 mice). g Proportions of stable (two-sided Wilcoxon signed-rank test, p = 0.017 and 5.8 × 10−4 for the reward and no-reward categories) and reversed neurons (p = 0.40 and 0.47 for the reward and no-reward categories, n = 7 mice) during two consecutive days. Dashed lines, chance level. Similar proportions of stable neurons in both categories (two-sided Wilcoxon signed-rank test, p = 0.053). Bars, mean ± SEM. h Lower decoding accuracies of odors with longer session intervals (two-sided Wilcoxon signed-rank test; reward category: p = 2.1 × 10−4, 5.6 × 10−3, 0.008, 0.03 for distance 1, 2, 3, 4, p = 0.001 for 0 vs. 1; no-reward category: p = 4.1 × 10−5, 0.006, 0.008, 0.03 for distance 1, 2, 3, 4, p = 7.8 × 10−4 for 0 vs. 1). Across-day decoding accuracies were similar between the categories (two-sided Wilcoxon signed-rank test, p = 0.71, n = 12 mice). Thin lines for each mouse. Thick lines for mean. i Within-session decoding accuracies. Each color, different mouse (n = 7 mice). Dashed lines (h and i) for shuffled data. j The within-day vs. across-day decoding accuracy difference (distance 0 vs. 1) was greater in the social task (mean ± SEM, two-sided Wilcoxon singed-rank test, p = 0.0072 and 0.017 for reward and no-reward category). *p < 0.05, **p < 0.01, ***p < 0.001, n.s., not significant. Source data are provided as a Source Data file.