Table 2.
Overview of differentially expressed genes after adjusting for age and sex.
| Gene symbol | Gene name | Entrez ID | log2FC | FC | adj.p-value |
|---|---|---|---|---|---|
| (A) Differentially expressed genes in SCZ vs HC | |||||
| Top 20 upregulated genes in schizophrenia | |||||
| OLFM4 | Olfactomedin 4 | 10562 | 0.72 | 1.64 | 0.001 |
| DEFA1 | Defensin alpha 1 | 1667 | 0.65 | 1.57 | 0.040 |
| ELANE | Elastase, neutrophil expressed | 1991 | 0.61 | 1.53 | 0.002 |
| CEACAM8 | Carcinoembryonic antigen related cell adhesion molecule 8 | 1088 | 0.59 | 1.50 | 0.009 |
| DEFA4 | Defensin alpha 4 | 1669 | 0.57 | 1.48 | 0.035 |
| CEACAM6 | Carcinoembryonic antigen related cell adhesion molecule 6 | 4680 | 0.52 | 1.44 | 0.003 |
| BPI | Bactericidal permeability increasing protein | 671 | 0.49 | 1.41 | 0.001 |
| CTSG | Cathepsin G | 1511 | 0.47 | 1.39 | 0.009 |
| SLPI | Secretory leukocyte peptidase inhibitor | 6590 | 0.45 | 1.37 | 1.16E−04 |
| CAMP | Cathelicidin Antimicrobial Peptide | 820 | 0.45 | 1.37 | 0.006 |
| PI3 | Peptidase inhibitor 3 | 5266 | 0.40 | 1.32 | 0.010 |
| TCN1 | Transcobalamin 1 | 6947 | 0.40 | 1.32 | 0.002 |
| LTF | Lactotransferrin | 4057 | 0.38 | 1.31 | 0.028 |
| MPO | Myeloperoxidase | 4353 | 0.38 | 1.30 | 0.006 |
| OLR1 | Oxidized low density lipoprotein receptor 1 | 4973 | 0.36 | 1.29 | 0.006 |
| HP | Haptoglobin | 3240 | 0.34 | 1.27 | 0.015 |
| AZU1 | Azurocidin 1 | 566 | 0.30 | 1.23 | 0.044 |
| MS4A3 | Membrane Spanning 4-Domains A3 | 932 | 0.28 | 1.21 | 0.044 |
| CYP1B1 | Cytochrome P450 Family 1 Subfamily B Member 1 | 1545 | 0.24 | 1.18 | 0.028 |
| FBN2 | Fibrillin 2 | 2201 | 0.21 | 1.15 | 0.037 |
| Top 20 downregulated genes in schizophrenia | |||||
| PTGDS | Prostaglandin D2 Synthase | 5730 | −0.48 | −1.39 | 3.66E−06 |
| LRRC26 | Leucine Rich Repeat Containing 26 | 389816 | −0.35 | −1.27 | 5.09E−06 |
| CDKN1C | Cyclin dependent kinase inhibitor 1C | 1028 | −0.32 | −1.25 | 0.003 |
| CD160 | CD160 Molecule | 11126 | −0.31 | −1.24 | 0.023 |
| FEZ1 | Fasciculation And Elongation Protein Zeta 1 | 9638 | −0.31 | −1.24 | 0.006 |
| AKR1C3 | Aldo-Keto Reductase Family 1 Member C3 | 8644 | −0.31 | −1.24 | 0.022 |
| SH2D1B | SH2 Domain Containing 1B | 117157 | −0.30 | −1.23 | 0.015 |
| CLIC3 | Chloride Intracellular Channel 3 | 9022 | −0.27 | −1.20 | 0.034 |
| LYPD2 | LY6/PLAUR Domain Containing 2 | 137797 | −0.25 | −1.19 | 0.010 |
| TAGLN | Transgelin | 6876 | −0.23 | −1.18 | 0.009 |
| PTGDR | Prostaglandin D2 Receptor | 5729 | −0.23 | −1.17 | 0.034 |
| PACSIN1 | Protein Kinase C And Casein Kinase Substrate In Neurons 1 | 29993 | −0.23 | −1.17 | 0.005 |
| TNFRSF21 | TNF Receptor Superfamily Member 21 | 27242 | −0.22 | −1.16 | 0.040 |
| MS4A7 | Membrane Spanning 4-Domains A7 | 58475 | −0.20 | −1.15 | 0.027 |
| AKR1C4 | Aldo-Keto Reductase Family 1 Member C4 | 1109 | −0.19 | −1.14 | 0.034 |
| PLEKHF1 | Pleckstrin Homology And FYVE Domain Containing 1 | 79156 | −0.19 | −1.14 | 0.044 |
| KLRB1 | Killer Cell Lectin Like Receptor B1 | 3820 | −0.18 | −1.13 | 0.046 |
| CEP78 | Centrosomal Protein 78 | 84131 | −0.18 | −1.13 | 0.034 |
| MYOF | Myoferlin | 26509 | −0.17 | −1.13 | 0.028 |
| DUSP5 | Dual Specificity Phosphatase 5 | 1847 | −0.16 | −1.12 | 0.015 |
| (B) Differentially expressed genes in BD vs HC | |||||
| Top 20 upregulated genes in bipolar disorder | |||||
| OLFM4 | Olfactomedin 4 | 10562 | 0.73 | 1.66 | 0.015 |
| ELANE | Elastase, neutrophil expressed | 1991 | 0.62 | 1.54 | 0.019 |
| SLPI | Secretory leukocyte peptidase inhibitor | 6590 | 0.59 | 1.50 | 4.51E−05 |
| CTSG | Cathepsin G | 1511 | 0.52 | 1.43 | 0.024 |
| CEACAM6 | Carcinoembryonic antigen related cell adhesion molecule 6 | 4680 | 0.52 | 1.43 | 0.034 |
| PI3 | Peptidase inhibitor 3 | 5266 | 0.52 | 1.43 | 0.009 |
| BPI | Bactericidal permeability increasing protein | 671 | 0.47 | 1.38 | 0.031 |
| CAMP | Cathelicidin Antimicrobial Peptide | 820 | 0.44 | 1.36 | 0.048 |
| MPO | Myeloperoxidase | 4353 | 0.40 | 1.32 | 0.028 |
| OLR1 | Oxidized low density lipoprotein receptor 1 | 4973 | 0.40 | 1.32 | 0.020 |
| RFX2 | Regulatory Factor X2 | 5990 | 0.28 | 1.21 | 0.010 |
| ADGRE1 | Adhesion G Protein-Coupled Receptor E1 | 2015 | 0.27 | 1.21 | 0.048 |
| H1-0 | H1.0 Linker Histone | 3005 | 0.25 | 1.19 | 0.027 |
| OSCAR | Osteoclast Associated Ig-Like Receptor | 126014 | 0.24 | 1.18 | 0.009 |
| PIM3 | Pim-3 Proto-Oncogene, Serine/Threonine Kinase | 415116 | 0.23 | 1.18 | 0.005 |
| SLC2A5 | Solute Carrier Family 2 Member 5 | 6518 | 0.23 | 1.17 | 0.048 |
| FAR2 | Fatty Acyl-CoA Reductase 2 | 55711 | 0.22 | 1.16 | 0.041 |
| GAS7 | Growth Arrest Specific 7 | 8522 | 0.21 | 1.16 | 0.009 |
| FES | FES Proto-Oncogene, Tyrosine Kinase | 2242 | 0.21 | 1.15 | 0.034 |
| ZNF438 | Zinc Finger Protein 438 | 220929 | 0.20 | 1.15 | 0.031 |
| Top 20 downregulated genes in bipolar disorder | |||||
| FGFBP2 | Fibroblast growth factor binding protein 2 | 83888 | −0.49 | −1.41 | 0.005 |
| ADGRG1 | Adhesion G protein-coupled receptor G1 | 9289 | −0.43 | −1.35 | 0.008 |
| KLRD1 | Killer Cell Lectin Like Receptor D1 | 3824 | −0.43 | −1.35 | 0.022 |
| GNLY | Granulysin | 10578 | −0.39 | −1.31 | 0.041 |
| PTGDS | Prostaglandin D2 Synthase | 5730 | −0.39 | −1.31 | 0.015 |
| CD160 | CD160 Molecule | 11126 | −0.38 | −1.30 | 0.017 |
| ITGB1BP1 | Integrin Subunit Beta 1 Binding Protein 1 | 9270 | −0.37 | −1.29 | 0.039 |
| HOPX | HOP Homeobox | 84525 | −0.36 | −1.29 | 0.009 |
| CDKN1C | Cyclin dependent kinase inhibitor 1C | 1028 | −0.36 | −1.28 | 0.010 |
| GZMB | Granzyme B | 3002 | −0.35 | −1.28 | 0.012 |
| S1PR5 | Sphingosine-1-Phosphate Receptor 5 | 53637 | −0.34 | −1.27 | 0.017 |
| CCL4 | C-C Motif Chemokine Ligand 4 | 6351 | −0.33 | −1.26 | 0.009 |
| FASLG | Fas Ligand | 356 | −0.32 | −1.25 | 0.010 |
| PRSS23 | Serine Protease 23 | 11098 | −0.31 | −1.24 | 0.047 |
| CLIC3 | Chloride Intracellular Channel 3 | 9022 | −0.31 | −1.24 | 0.043 |
| CCL4L2 | C-C Motif Chemokine Ligand 4 Like 2 | 9560 | −0.30 | −1.23 | 0.022 |
| PRF1 | Perforin 1 | 5551 | −0.30 | −1.23 | 0.016 |
| IFNG | Interferon Gamma | 3458 | −0.30 | −1.23 | 0.042 |
| NKG7 | Natural Killer Cell Granule Protein 7 | 4818 | −0.30 | −1.23 | 0.010 |
| SAMD3 | Sterile Alpha Motif Domain Containing 3 | 154075 | −0.29 | −1.22 | 0.013 |
SCZ schizophrenia, BD bipolar disorder, HC healthy control, FC fold change.
Downregulated genes are calculated as −1/FC. Adj.p-value is Bonferroni-adjusted p-value.