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. 2022 Nov 21;141(12):1389–1401. doi: 10.1182/blood.2021015111

Figure 1.

Figure 1.

Protocol schema. The rhIL-22 dimer F-652 was administered weekly for a total of 4 doses in combination with systemic corticosteroids to patients with newly diagnosed GI aGVHD. Patients were monitored for safety, drug PK, clinical endpoints including day-28 aGVHD response rates, and correlative analyses including fecal microbiota composition.