Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Apr 24;136(8):jcs260353. doi: 10.1242/jcs.260353

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2023. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

PMC Copyright notice

Fig. 1. — Calcineurin is proximal to centrosome proteins. (A) Scheme for cell cycle synchronization and PDB–MS. Amino acid residues mutated in the PxIxIT recognition pocket are indicted. Async, asynchronous; M, mitosis. (B) Heat map showing average spectral counts (AvgSpec) of the CN-proximal proteins (from DDA mass spectrometry) in each of the indicated experimental conditions. Proteins with PxIxIT docking-dependent biotinylation [log₂ spectral count ratio (CNAα_WT/CNAα_NIRmut)≥0.5] are shown in bold type. Proteins annotated by the GO term ‘centrosome’ are shown in red. Asterisks indicate proteins containing PxIxIT or LxVP motifs. Mit, mitosis. (C) Cellular component GO terms with statistically significant enrichment among the CN-proximal proteins. The number of CN-proximal proteins assigned to each term is plotted, and the FDR is indicated. (D) CN-proximal proteins with previously reported localization to centrosomes, cilia or mitotic spindles. See Table S2 for references. (E) Overlap of centrosome and cilia CN-proximal proteins from Wigington et al. (2020) (pink circle) and this study (blue).