Table 1. Clinical Characteristics of Patients After Lung Transplantation.
| Characteristics | Patients, No. (%) | ||
|---|---|---|---|
| All patients (N = 504) | Training set (n = 353) | Test set (n = 151) | |
| Age, mean (SD), y | 55.56 (12.27) | 55.03 (12.78) | 56.79 (10.95) |
| Sex | |||
| Male | 334 (66.3) | 235 (66.6) | 99 (65.6) |
| Female | 170 (33.7) | 118 (33.4) | 52 (34.4) |
| Body mass index, mean (SD)a | 20.54 (3.52) | 20.33 (3.54) | 21.02 (3.42) |
| Diagnosis | |||
| Interstitial pulmonary fibrosis | 275 (54.6) | 191 (54.1) | 84 (55.6) |
| Chronic obstructive pulmonary diseases | 98 (19.4) | 67 (19.0) | 31 (20.5) |
| Pulmonary arterial hypertension | 15 (3.0) | 13 (3.7) | 2 (1.3) |
| Pneumoconiosis | 61 (12.1) | 44 (12.5) | 17 (11.3) |
| Others | 55 (10.9) | 38 (10.7) | 17 (11.3) |
| Surgical approach | |||
| Lateral sequential | 401 (79.5) | 278 (78.7) | 123 (81.5) |
| Supine sequential | 94 (18.7) | 67 (19.0) | 27 (17.9) |
| Clamshell | 9 (1.8) | 8 (2.3) | 1 (0.6) |
| Surgical type | |||
| Single lung transplantation | 236 (46.8) | 164 (46.5) | 72 (47.7) |
| Double lung transplantation | 268 (53.2) | 189 (53.5) | 79 (52.3) |
| ECMO type | |||
| Venovenous | 233 (46.2) | 155 (43.9) | 78 (51.7) |
| Venoarterial | 131 (26.0) | 103 (29.2) | 28 (18.5) |
| None | 140 (27.8) | 95 (26.9) | 45 (29.8) |
| 72 h PGD3 | |||
| No | 381 (75.6) | 262 (74.2) | 119 (78.8) |
| Yes | 123 (24.4) | 91 (25.8) | 32 (21.2) |
| Preoperative hormone use | |||
| No | 293 (58.1) | 207 (58.6) | 86 (57.0) |
| Yes | 211 (41.9) | 146 (41.4) | 65 (43.0) |
| Multidrug-resistant bacterial infection | |||
| No | 46 (9.1) | 35 (10.0) | 11 (7.3) |
| Yes | 458 (90.9) | 318 (90.0) | 140 (92.7) |
| Operation time, mean (SD), min | 336.5 (99.41) | 338.75 (98.33) | 331.24 (102.01) |
| Postoperative ECMO time, mean (SD), d | 1.38 (2.13) | 1.44 (2.12) | 1.24 (2.14) |
| Postoperative ventilator time, mean (SD), d | 5.78 (12.9) | 5.87 (12.74) | 5.56 (13.31) |
| ICU stay, mean (SD), d | 7.5 (9.59) | 7.62 (9.84) | 7.22 (8.99) |
| 6MWT, mean (SD), m | 462.62 (77.54) | 465.73 (79.13) | 455.33 (73.42) |
| Cold-ischemia time, mean (SD), h | 7.58 (2.02) | 7.59 (1.98) | 7.55 (2.14) |
| Donor Pao2/Fio2, mean (SD) | 440.43 (70.63) | 440.82 (69.85) | 439.52 (72.63) |
| FEV1, mean (SD) | 2.04 (0.54) | 2.06 (0.56) | 2.01 (0.48) |
| FEV1%, mean (SD) | 0.67 (0.16) | 0.67 (0.16) | 0.68 (0.14) |
| FVC, mean (SD) | 2.49 (0.63) | 2.51 (0.65) | 2.42 (0.57) |
| FVC%, mean (SD) | 0.66 (0.15) | 0.66 (0.15) | 0.66 (0.13) |
| FEV1/FVC, mean (SD) | 0.83 (0.1) | 0.82 (0.1) | 0.84 (0.08) |
Abbreviations: ECMO, extracorporeal membrane oxygenation; FEV1, forced expiratory volume in 1 second; FEV1%, percentage of predicted forced expiratory volume in 1-second value; FVC, forced vital capacity; FVC%, percentage of predicted forced vital capacity value; ICU, intensive care unit; Pao2/Fio2, arterial oxygen tension/inspired oxygen fraction; 6MWT, 6-minute walking test; 72 h PGD3, grade 3 primary graft dysfunction at 72h.
a
Body mass index is calculated as weight in kilograms divided by height in meters squared.