Fig. 1.

Design, formulation optimization, characterization and release kinetics of SIL@T. A) Design schematic of SIL@T. B) Effects of different mass ratios of polymer materials and SIL on particle size and PDI of micelles. C) Effects of different mass ratios of polymer materials and SIL on the zeta potential of micelles and drug loading of SIL. D) Particle size distribution and TEM images of SIL@T. E) Variation in particle size of micelles in a simulated metastatic tumor cytoplasmic environment. F) Release profile of OXA and SIL(G) at different time under simulated plasma environment, endosome/lysosomal environment, and cytoplasmic environment. Data are presented as means ± SD (n = 3).