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. 2023 Apr 27;27:474–487. doi: 10.1016/j.bioactmat.2023.04.021

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© 2023 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Fig. 4 — SIL@T can induce ICD and inhibit STAT3 phosphorylation on tumor cells. A) Effects of different preparations on the viability of 4T1-Br-Luc cells (n = 6). B) Scheme of the effect of SIL@T at the cellular level. C) Effects of different preparations on STAT3 phosphorylation in 4T1-Br-Luc cells. D) Investigation on the induction of HMGB1 release from 4T1-Br-Luc cells by different preparations. E) Fluorescence imaging of HMGB1 release from 4T1-Br-Luc cells induced by different preparations. Blue: nucleus; green: HMGB1. Scale bar: 20 μm. F) Fluorescence imaging of CRT translocation induced by different preparations in 4T1-Br-Luc cells. Blue: nucleus; red: CRT. Scale bar: 20 μm.