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. 2023 Apr 27;27:474–487. doi: 10.1016/j.bioactmat.2023.04.021

Fig. 6.

Fig. 6

SIL@T can inhibit the phosphorylation of STAT3 and reverse the immunosuppressive microenvironment. A) Scheme of SIL@T reversing immunosuppression. B) Immunofluorescence imaging of pSTAT3 in brain cryosections of BM-mice. Blue: nucleus; yellow: pSTAT3. Scale bar: 100 μm. C) ELISA results of TGF-β content in metastases (n = 4, One-way ANOVA, **P < 0.01). D) WB results of pSTAT3, iNOS and CD206 proteins in metastases. E) Flow cytometry analysis of M1 polarization of TAM in brain metastases. F) Immunofluorescence imaging of CD8+ T cell infiltration in brain cryosections of BM-mice. Blue: nucleus; red: Foxp3. Scale bar: 100 μm.