Table 1.

Timeline of enrolment, intervention and assessment schedule

NC7+iSLT (group A: experimental group)
Time point	Visit 1 (eligibility screening)	Visit 2 (baseline)	Visit 3 (3 days+1 day post-NC7)	Visit 4 (3 weeks±3 days post-iSLT onset)	Visit 5 (24 weeks±7 days post-iSLT onset)
Informed consent	√
Inclusion and exclusion criteria scrutiny	√
Demographic information	√
General physical examination	√
Primary outcome		√	√	√	√
Secondary outcomes		√	√	√	√
Safety outcomes		√	√	√	√
Brain plasticity evaluation		√		√	√

iSLT alone (group B: control group)
Time point	Visit 1 (eligibility screening)	Visit 2 (baseline)	Visit 3 (3 days+1 day, waiting periods onset)	Visit 4 (3 weeks±3 days post-iSLT onset)	Visit 5 (24 weeks±7 days post-iSLT onset)
Informed consent	√
Inclusion and exclusion criteria scurtiny	√
Demographic information	√
General physical examination	√
Primary outcome		√	√	√	√
Secondary outcomes		√	√	√	√
Safety assessment		√	√	√	√
Brain plasticity evaluation		√		√	√

iSLT, intensive speech and language therapy; NC7, C7 neurotomy.;