Table 1.
Interrupted time-series analysis of monoclonal antibodies and antivirals drugs use across two different time segments: pre- and post-end of Delta variant, in England and Italy
Country | βb | Prevalence ratio | 95% CI | p-Value |
p-Value (Italy versus England) |
|
---|---|---|---|---|---|---|
Bamlaniviamb/etesevimaba | Italy | – | – | – | – | – |
England | – | – | – | – | ||
Sotrovimab | Italy | 0.080 | 1.083 | 1.052–1.116 | < 0.001 | < 0.001 |
England | 1.491 | 4.445 | 4.322–4.572 | < 0.001 | ||
Tixagevimab/cilgavimaba | Italy | – | – | – | – | – |
England | – | – | – | – | ||
Casirivimab/imdevimab | Italy | −1.630 | 0.195 | 0.180–0.212 | < 0.001 | – |
Englanda | – | – | – | – | ||
Remdesivir | Italy | 0.963 | 2.619 | 2.521–2.718 | < 0.001 | < 0.001 |
England | 2.228 | 9.281 | 6.896–12.553 | < 0.001 | ||
Molnupiravir | Italy | 0.931 | 2.537 | 2.479–2.596 | < 0.001 | < 0.001 |
England | 1.448 | 4.254 | 4.100–4.410 | < 0.001 | ||
Nirmatrelvir/ritonavir | Italy | 2.210 | 9.115 | 8.846–9.393 | < 0.001 | 0.440 |
England | 2.220 | 9.207 | 8.935–9.487 | 0.010 |
CI confidence interval
aNot applicable
bLevel change parameter