for the main comparison.

Isoflavones for hypercholesterolaemia in adults
Patient or population: postmenopausal women with hypercholesterolaemia Settings: outpatients or not specified Intervention: isoflavones or soy protein‐containing isoflavones Comparison: placebo or soy protein
Outcomes	Relative effect (95% CI)	No of participants (studies)	Quality of the evidence (GRADE)	Comments
Cardiovascular events	See comment	See comment	See comment	Not investigated
Death from any cause	See comment	See comment	See comment	Not investigated
Health‐related quality of life	See comment	See comment	See comment	Not investigated
Adverse events [follow‐up: 3 to 6 months]	See comment	208 (5)	⊕⊕⊝⊝ lowa	No serious adverse events reported
Low‐density lipoprotein (LDL) cholesterol [follow‐up: 3 to 6 months]	See comment	132 (3)	⊕⊝⊝⊝ very lowb	No statistically significant differences between groups
Costs	See comment	See comment	See comment	Not investigated
GRADE Working Group grades of evidence High quality: Further research is very unlikely to change our confidence in the estimate of effect. Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low quality: We are very uncertain about the estimate.

^aDue to serious risk of bias, low number of participants and studies, short duration of treatment.

^bDue to serious risk of bias, serious indirectness, low number of participants and studies, short duration of treatment.