1. Overview of study populations.

Characteristic Study ID	Intervention and comparator	[N] Screened / eligible	[N] Randomised	[N] Safety	[N] ITT	[N] Finishing study	[%] Randomised finishing study
Aubertin‐Leheudre 2008	Isoflavones (70 mg)	‐	‐	‐	‐	8	N/A
	Placebo		‐	‐	‐	11	N/A
total:			‐	‐	‐	19	N/A
Dewell 2002	Isoflavones (150 mg)	‐	20	‐	20	20	100
	Maltodextrin with 10% caramel		16	‐	16	16	100
total:			36	‐	36	36	100
Gardner 2001	Isoflavones (80 mg)	‐	34	‐	‐	31	91.2
	Trace amounts of isoflavones		34	‐	‐	33	97.1
total:			68	‐	‐	64	94.1
Mackey 2000	Isoflavones (65 mg)	‐	‐	‐	‐	25	N/A
	Less than 4 mg isoflavones		‐	‐	‐	24	N/A
total:			54	‐	‐	49	90.7
Wang 2005	Isoflavones (158 mg)	‐	20	‐	20	20	100
	Placebo		20	‐	20	20	100
total:			40	‐	40	40	100
Total	All interventions		‐			104
	All controls		‐			104
	All interventions and comparators		‐			208

"‐" denotes not reported.

ITT: intention‐to‐treat; N/A: not applicable.