Comparison 1. Isoflavones versus placebo or soy protein+isoflavones versus soy protein.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 LDL‐cholesterol	3	132	Mean Difference (IV, Random, 95% CI)	‐0.16 [‐0.39, 0.07]
1.1 Isoflavones versus placebo	1	19	Mean Difference (IV, Random, 95% CI)	0.05 [‐0.43, 0.53]
1.2 Soy protein‐containing isoflavones versus soy protein	2	113	Mean Difference (IV, Random, 95% CI)	‐0.23 [‐0.50, 0.04]
2 Total cholesterol	4	166	Mean Difference (IV, Random, 95% CI)	‐0.08 [‐0.34, 0.19]
2.1 Isoflavones versus placebo	2	53	Mean Difference (IV, Random, 95% CI)	0.12 [‐0.44, 0.68]
2.2 Soy protein‐containing isoflavones versus soy protein	2	113	Mean Difference (IV, Random, 95% CI)	‐0.20 [‐0.50, 0.09]
3 HDL‐cholesterol	3	132	Mean Difference (IV, Random, 95% CI)	‐0.03 [‐0.22, 0.16]
3.1 Isoflavones versus placebo	1	19	Mean Difference (IV, Random, 95% CI)	‐0.07 [‐0.38, 0.24]
3.2 Soy protein‐containing isoflavones versus soy protein	2	113	Mean Difference (IV, Random, 95% CI)	‐0.03 [‐0.30, 0.25]
4 Triglycerides	4	165	Mean Difference (IV, Random, 95% CI)	‐0.15 [‐0.43, 0.13]
4.1 Isoflavones versus placebo	2	52	Mean Difference (IV, Random, 95% CI)	‐0.46 [‐0.84, ‐0.09]
4.2 Soy protein‐containing isoflavones versus soy protein	2	113	Mean Difference (IV, Random, 95% CI)	0.03 [‐0.23, 0.29]
5 Sex hormone binding globulin	1	46	Mean Difference (IV, Random, 95% CI)	‐4.22 [‐15.62, 7.18]