Wang 2005.

Methods	Parallel randomised controlled clinical trial, randomisation ratio 1 : 1
Participants	Inclusion criteria: postmenopausal women (≥ 6 months since their last menstrual cycle) with perimenopausal symptoms, dyslipidaemia and abnormal endocrine function, aged 45‐55 years Exclusion criteria: use of steroid drugs Diagnostic criteria: not specified
Interventions	Number of study centres: 1 Treatment before study: no Titration period: 3 month
Outcomes	Outcomes reported in abstract of publication: serum TC, HDL‐C, LDL‐C and triacylglycerol
Study details	Run‐in period: no Study terminated before regular end (for benefit/because of adverse events): no
Publication details	Language of publication: Chinese Commercial/non‐commercial/other funding: not reported Publication status: peer‐reviewed journal
Stated aim of study	Quote from publication: "To study the effects of soybean isoflavones on lipids metabolism in the perimenopausal female"
Notes	Baseline serum HDL‐C concentrations were very low
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Quote from publication: "Subjects were randomised to 3 groups" Comment: no information about sequence generation
Allocation concealment (selection bias)	Unclear risk	Comment: no information about concealment
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Quote from publication:"The placebo group consumed the placebo capsules that looked like the isoflavones capsules" Comment: participants and personnel were potentially masked
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Comment: no information about blinding
Incomplete outcome data (attrition bias) All outcomes	Low risk	Comment: number of participants analyzed was equal to the number of participants randomized
Selective reporting (reporting bias)	Low risk	Comment: none detected
Other bias	Low risk	Comment: no other sources of bias were found in this study