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. Author manuscript; available in PMC: 2023 May 6.
Published in final edited form as: Science. 2023 Jan 12;379(6628):201–206. doi: 10.1126/science.add3598

Figure 3. GOF PIEZO2 in sensory neurons causes limb defects.

Figure 3.

(A) Phalange-metacarpal joint angle of the hindlimbs in wild type and tissue specific GOF mice (black: wild type; red: GOF Piezo2). (B) Tendon length of hindlimbs. (C) Quantification of hanging wire test results. (D) Quantification of inverted screen test results. (E) Tamoxifen induction of GOF PIEZO2 in proprioceptive neurons by AdvillinCre-ERT2 at various developmental stages. (F) Phalange-metacarpal joint angle of the hindlimbs in E. (G) Quantification of hanging wire test results in E. (H) Quantification of inverted screen test in E. *p < 0.05, **p < 0.01, and ***p < 0.001 (One-way ANOVA followed by Tukey’s multiple comparison). Each data point represents a single animal.