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. Author manuscript; available in PMC: 2023 May 6.
Published in final edited form as: Science. 2023 Jan 12;379(6628):201–206. doi: 10.1126/science.add3598

Figure 5. EPA diet rescues joint defects in GOF mice.

Figure 5.

(A) Mechanically activated currents in N2APiezo1−/− cells heterologously expressing mouse PIEZO2 wild type (stippled) and GOF mutants S2763R (green) and E2799del (brown). (B) Quantification of the inactivation time constant results in A. (C) Phalange-metacarpal joint angle of the hindlimbs in young adult wild type and GOF Piezo2; PvalbCre mice that received EPA-enriched diet. Control: sunflower-oil-based food, which has a similar level of fat content and energy. (D) Quantification of hanging wire and inverted screen test results in C. *p < 0.05, **p < 0.01, and ***p < 0.001 (Two-way ANOVA followed by Tukey honestly significance test).