Table 2.
Association of anthropometric measures with overall and breast cancer-specific mortality
| Overall mortality | Breast cancer mortality | |||
|---|---|---|---|---|
| HRa | 95% CI | HRb | 95% CI | |
| Independent association of the anthropometric measurement | ||||
| Body Mass Index1 | ||||
| Underweight | 1.10 | (0.79–1.52) | 1.25 | (0.79–1.97) |
| Overweight | 1.09 | (0.99–1.19) | 1.13 | (1.00–1.28) |
| Obesity | 1.26 | (1.12–1.43) | 1.23 | (1.04–1.46) |
| Per 5 kg/m2 increase | 1.10 | (1.05–1.15) | 1.07 | (1.00–1.15) |
| Waist Circumference2 | ||||
| > 88 cm | 1.25 | (1.12–1.40) | 1.17 | (1.01–1.35) |
| Per 10 cm increase | 1.11 | (1.06–1.16) | 1.07 | (1.01–1.14) |
| ABSI2 | ||||
| High | 1.23 | (1.11–1.37) | 1.13 | (0.98–1.30) |
| Per 1 SD increase | 1.09 | (1.04–1.14) | 1.04 | (0.97–1.11) |
| Model with Body Mass Index and ABSI2 | ||||
| Body Mass Index | ||||
| Underweight | 1.29 | (0.87–1.91) | 1.35 | (0.79–2.30) |
| Overweight | 1.04 | (0.94–1.16) | 1.09 | (0.95–1.25) |
| Obesity | 1.25 | (1.09–1.43) | 1.23 | (1.03–1.47) |
| ABSI | ||||
| High | 1.22 | (1.10–1.35) | 1.11 | (0.96–1.28) |
| Premenopausal3 | ||||
| Body Mass Index | ||||
| Underweight | 1.17 | (0.54–2.53) | 1.25 | (0.50–3.11) |
| Overweight | 1.06 | (0.81–1.39) | 0.98 | (0.72–1.33) |
| Obesity | 1.11 | (0.77–1.61) | 0.97 | (0.63–1.49) |
| ABSI | ||||
| High | 1.24 | (0.94–1.63) | 1.15 | (0.83–1.59) |
| Postmenopausal4 | ||||
| Body Mass Index | ||||
| Underweight | 1.46 | (0.92–2.32) | 1.60 | (0.83–3.08) |
| Overweight | 1.04 | (0.92–1.17) | 1.11 | (0.95–1.30) |
| Obesity | 1.26 | (1.09–1.46) | 1.30 | (1.06–1.59) |
| ABSI | ||||
| High | 1.20 | (1.07–1.35) | 1.10 | (0.94–1.28) |
Abbreviations: ABSI, A Body Shape Index; HR, Hazard Ratio; CI, Confidence Interval
Reference levels for categorical variables: Body Mass Index - Normal weight 18.5-<25 kg/m2, Waist circumference <=88cm, ABSI - Low (<= 76.04, 75th Percentile)
1N = 13,624/2425 Deaths (1241 normal weight)/1354 BC deaths (665 normal weight)
2N = 9708/1850 Deaths (862 normal weight)/1111 BC deaths (511 normal weight)
3N = 1904/339 Deaths (207 normal weight)/261 BC deaths (163 normal weight)
4N = 7804/1511 Deaths (655 normal weight)/850 BC deaths (348 normal weight)
aHazard Ratios from the multivariable Cox regression model
bSubdistribution Hazard Ratios from the multivariable Fine and Gray regression model