Table 4.
Association of post-diagnosis Body Mass Index with overall mortality and breast cancer-specific mortality
| Overall mortality | Breast cancer mortality | |||
|---|---|---|---|---|
| HRa | 95% CI | HRb | 95% CI | |
| Body mass index | ||||
| Underweight | 0.88 | (0.35–2.20) | 0.35 | (0.06–2.04) |
| Overweight | 1.03 | (0.82–1.30) | 0.79 | (0.59–1.07) |
| Obesity | 1.32 | (0.98–1.77) | 1.18 | (0.80–1.73) |
| Per 5 kg/m2 increase | 1.13 | (1.01–1.27) | 1.09 | (0.93–1.28) |
| % Annual weight change | ||||
| Lowest tertile (< 0) | 1.45 | (1.13–1.87) | 1.41 | (0.99–2.00) |
| Highest tertile (≥ 0.96) | 1.30 | (1.00–1.67) | 1.27 | (0.91–1.79) |
Abbreviations: HR, Hazard Ratio; CI, Confidence Interval
N = 1878/432 Deaths (214 normal weight) -/241 BC deaths (124 normal weight)
Weight assessment gathered between 6 months and 4 years post diagnosis
Reference level for categorical Body Mass Index: Normal weight 18.5-<25kg/m2
Reference level for % annual weight change: Middle tertile (0- < 0.96)
aHazard Ratios from the multivariable Cox regression model further adjusted by pre-diagnosis Body Mass Index and time from diagnosis to second weight assessment
bSubdistribution Hazard Ratios from the multivariable Fine and Gray regression model further adjusted by Body Mass Index and time from diagnosis to second weight assessment