Table 2.

Factors favoring ICIs vs. TT

	ICIs	Target therapy
Rate of objective response	Lower	Higher
Onset of action	Slower	Faster
Profound response	Higher	Lower
Level of disease control	Higher	Lower
Duration of response	Higher	Lower
Control of disease even after treatment discontinuation	Yes	Not
Grade 3–5 toxicities		Fewer
Reversible toxicities		Spesso
Treat patients with autoimmune conditions and on immunosuppressive therapies	To evaluate	Yes