Table 2.
Bortezomib, Everolimus and Fludarabine gene targets are overexpressed in glioma
| Gene | Cancer tissue sample | Number of samples | Corresponding tissue sample | Number of samples | Total measured genes | Mean fold change (Log2) | p value | Sample type | Platform | Study |
|---|---|---|---|---|---|---|---|---|---|---|
| Bortezomib | ||||||||||
| NFKB1 | AOA | 6 | Normal Brain | 4 | 14,836 | 1.413 | 0.041 | mRNA | ND | Bredel Brain 2 |
| NFKB1 | A | 45 | Normal Brain | 6 | 5338 | 1.594 | 0.018 | mRNA | Human Gene FL Array | Rickman Brain |
| NFKB1 | GBM | 27 | Normal Brain | 4 | 14,836 | 1.778 | 1.39E−04 | mRNA | ND | Bredel Brain 2 |
| NFKB1 | GBM | 30 | Normal Brain | 3 | 9957 | 1.301 | 0.043 | mRNA | ND | Liang Brain |
| NFKB1 | GBM | 80 | Normal Brain | 4 | 19,574 | 1.362 | 2.55E−04 | mRNA | Human Genome U133 Plus 2.0 Array | Murat Brain |
| NFKB1 | GBM | 27 | Normal Brain | 7 | 8603 | 1.281 | 0.021 | mRNA | Human Genome U95-Av2 Array | Shai Brain |
| NFKB1 | GBM | 81 | Normal Brain | 23 | 19,574 | 1.166 | 0.004 | mRNA | Human Genome U133 Plus 2.0 Array | Sun Brain |
| NFKB1 | GBM | 542 | Normal Brain | 10 | 12,624 | 2.048 | 4.43E−09 | mRNA | Human Genome U133A Array | TCGA Brain |
| NOXA | AA | 19 | Normal Brain | 23 | 19,574 | 1.648 | 0.006 | mRNA | Human Genome U133 Plus 2.0 Array | Sun Brain |
| NOXA | A | 44 | Normal Brain | 6 | 5338 | 3.695 | 0.031 | mRNA | Human Gene FL Array | Rickman Brain |
| NOXA | DA | 7 | Normal Brain | 23 | 19,574 | 3.352 | 0.002 | mRNA | Human Genome U133 Plus 2.0 Array | Sun Brain |
| NOXA | GBM | 80 | Normal Brain | 4 | 19,574 | 1.378 | 3.81E−05 | mRNA | Human Genome U133 Plus 2.0 Array | Murat Brain |
| NOXA | GBM | 81 | Normal Brain | 23 | 19,574 | 1.643 | 0.005 | mRNA | Human Genome U133 Plus 2.0 Array | Sun Brain |
| NOXA | GBM | 542 | Normal Brain | 10 | 12,624 | 1.613 | 1.71E−08 | mRNA | Human Genome U133A Array | TCGA Brain |
| NOXA | OD | 50 | Normal Brain | 23 | 19,574 | 1.59 | 0.005 | mRNA | Human Genome U133 Plus 2.0 Array | Sun Brain |
| AKT | GBM | 542 | Normal Brain | 10 | 12,624 | 1.534 | 3.02E−13 | mRNA | Human Genome U133A Array | TCGA Brain |
| AKT | AOD | 3 | Normal Brain | 4 | 14,836 | 1.856 | 0.001 | mRNA | ND | Bredel Brain 2 |
| AKT | OD | 5 | Normal Brain | 4 | 14,836 | 1.450 | 0.005 | mRNA | ND | Bredel Brain 2 |
| AKT | GBM | 27 | Normal Brain | 4 | 14,836 | 1.183 | 0.012 | mRNA | ND | Bredel Brain 2 |
| AKT | PA | 8 | Normal Brain | 3 | 8603 | 1.579 | 0.017 | mRNA | Human Genome U95A-Av2 Array | Gutmann Brain |
| AKT | A | 45 | Normal Brain | 6 | 5338 | 1.107 | 0.015 | mRNA | Human Gene FL Array | Rickman Brain |
| AKT | GBM | 27 | Normal Brain | 7 | 8603 | 1.359 | 6.91E−4 | mRNA | Human Genome U95A-Av2 Array | Shai Brain |
| AKT | GBM | 81 | Normal Brain | 23 | 19,574 | 1.305 | 1.90E−7 | mRNA | Human Genome U133 Plus 2.0 Array | Sun Brain |
| AKT | OD | 50 | Normal Brain | 23 | 19,574 | 1.205 | 7.81E−6 | mRNA | Human Genome U133 Plus 2.0 Array | Sun Brain |
| AKT | AOD | 23 | Normal Brain | 6 | 19,574 | 1.541 | 1.50E−4 | mRNA | Human Genome U133 Plus 2.0 Array | French Brain |
| AKT | GBM | 80 | Normal Brain | 4 | 19,574 | 1.431 | 4.01E−4 | mRNA | Human Genome U133 Plus 2.0 Array | Murat Brain |
| Everolimus | ||||||||||
| MTOR | A | 5 | Normal Brain | 7 | 8603 | 1.452 | 0.004 | mRNA | Human Genome U95-AVr Array | Shai Brain |
| MTOR | DA | 7 | Normal brain | 23 | 19,574 | 2.094 | 0.005 | mRNA | Human Genome U133 Plus 2.0 Array | Sun Brain |
| MTOR | GBM | 22 | Normal Brain | 3 | 19,574 | 2.809 | 9.26E−07 | mRNA | Human Genome U133 Plus 2.0 Array | Lee Brain |
| MTOR | GBM | 27 | Normal Brain | 7 | 8603 | 1.292 | 2.37E−04 | mRNA | Human Genome U95-Av2 Array | Shai Brain |
| MTOR | GBM | 81 | Normal Brain | 23 | 19,574 | 1.777 | 0.002 | mRNA | Human Genome U133 Plus 2.0 Array | Sun Brain |
| Fludarabine | ||||||||||
| RRM1 | A | 5 | Normal Brain | 7 | 8603 | 1.146 | 0.031 | mRNA | Human Genome U95-Av2 Array | Shai Brain |
| RRM1 | OD | 3 | Normal Brain | 3 | 8603 | 1.394 | 0.03 | mRNA | Human Genome U95-Av2 Array | Shai Brain |
| RRM1 | GBM | 27 | Normal Brain | 7 | 8603 | 1.494 | 1.64E−05 | mRNA | Human Genome U95-Av2 Array | Shai Brain |
| RRM1 | A | 45 | Normal Brain | 6 | 5338 | 2.913 | 0.002 | mRNA | Human Gene FL Array | Rickman Brain |
| RRM1 | GBM | 30 | Normal Brain | 3 | 9957 | 1.368 | 5.50E−04 | mRNA | ND | Liang Brain |
| RRM1 | GBM | 80 | Normal Brain | 4 | 19,574 | 2.014 | 3.58E−05 | mRNA | Human Genome U133 Plus 2.0 Array | Murat Brain |
| RRM1 | OD | 50 | Normal Brain | 23 | 19,574 | 1.442 | 7.37E−05 | mRNA | Human Genome U133 Plus 2.0 Array | Sun Brain |
| RRM1 | AA | 19 | Normal Brain | 23 | 19,574 | 1.672 | 2.61E−05 | mRNA | Human Genome U133 Plus 2.0 Array | Sun Brain |
| RRM1 | GBM | 81 | Normal Brain | 23 | 19,574 | 2.013 | 2.21E−11 | mRNA | Human Genome U133 Plus 2.0 Array | Sun Brain |
| RRM1 | GBM | 542 | Normal Brain | 10 | 12,624 | 3.231 | 9.25E−10 | mRNA | Human Genome U133A Array | TCGA Brain |
| RRM1 | AOD | 23 | Normal Brain | 6 | 19,574 | 2.302 | 1.18E−06 | mRNA | Human Genome U133 Plus 2.0 Array | French Brain |
| RRM1 | AOA | 4 | Normal Brain | 6 | 19,574 | 2.011 | 6.17E−05 | mRNA | Human Genome U133 Plus 2.0 Array | French Brain |
| POLA1 | AA | 19 | Normal Brain | 23 | 19,574 | 1.665 | 7.69E−10 | mRNA | Human Genome U133 Plus 2.0 Array | Sun Brain |
| POLA1 | GBM | 81 | Normal Brain | 23 | 19,574 | 1.492 | 5.70E−09 | mRNA | Human Genome U133 Plus 2.0 Array | Sun Brain |
| POLA1 | QD | 50 | Normal Brain | 23 | 19,574 | 1.338 | 1.52E−05 | mRNA | Human Genome U133 Plus 2.0 Array | Sun Brain |
| POLA1 | DA | 7 | Normal Brain | 23 | 19,574 | 1.264 | 7.40E−02 | mRNA | Human Genome U133 Plus 2.0 Array | Sun Brain |
| POLA1 | GBM | 80 | Normal Brain | 4 | 19,574 | 1.9982 | 8.69E−08 | mRNA | Human Genome U133 Plus 2.0 Array | Murat Brain |
| POLA1 | GBM | 27 | Normal Brain | 7 | 8603 | 1.394 | 8.35E−04 | mRNA | Human Genome U95-Av2 Array | Shai Brain |
| POLA1 | OD | 3 | Normal Brain | 7 | 8603 | 1.585 | 1.00E−02 | mRNA | Human Genome U95-Av2 Array | Shai Brain |
| POLA1 | AA | 5 | Normal Brain | 7 | 8603 | 1.233 | 2.30E−02 | mRNA | Human Genome U95-Av2 Array | Shai Brain |
| POLA1 | GBM | 542 | Normal Brain | 10 | 12,624 | 1.756 | 1.79E−07 | mRNA | Human Genome U133A Array | TCGA |
| POLA1 | AOA | 4 | Normal Brain | 6 | 19,574 | 1.389 | 1.40E−02 | mRNA | Human Genome U133 Plus 2.0 Array | French Brain |
| POLA1 | AOD | 23 | Normal Brain | 6 | 19,574 | 1.303 | 0.013 | mRNA | Human Genome U133 Plus 2.0 Array | French Brain |
| DCK | OD | 3 | Normal Brain | 7 | 8603 | 1.426 | 9.48E−04 | mRNA | Human Genome U95A-Av2 Array | Shai Brain |
| DCK | A | 5 | Normal Brain | 7 | 8603 | 1.274 | 1.00E−02 | mRNA | Human Genome U95A-Av2 Array | Shai Brain |
| DCK | GBM | 542 | Normal Brain | 10 | 12,624 | 1.162 | 2.80E−02 | mRNA | Human Genome U133A Array | TCGA Brain |
mRNA expression levels of bortezomib, everolimus and fludarabine gene targets regulators was examined in glioma and normal brain tissue within the Oncomine database. Displayed in this table are the mean fold changes versus normal brain in each study and overall p value in that dataset. Gene expression data are log transformed and normalized as previously described
ND not defined