Table 1.

Opportunities for accelerating declines in in cancer death rates in the U.S.

Cancer Type	Outcome	Potential intervention type	Opportunity?
All Cancers	Incidence	Modifiable risk factors	Reduce smoking, obesity, physical inactivity & alcohol consumption
Lung	Incidence	Modifiable risk factors	Increase smoking cessation; prevent initiation
	Mortality	Screening (Early detection)	Increase low-dose CT uptake and reduce disparities in use
		Treatment	Reduce disparities in access to more effective treatments (targeted and immune-based therapies for NSCLC)
Colorectal	Incidence	Screening (Prevention)	Increase uptake of colonoscopy, flexible sigmoidoscopy, and FIT/FIT-DNA for hard-to-reach populations
		Preventive treatment	Increase adherence to diagnostic follow-up and polyp removal
	Mortality	Screening (Early detection)	Increase uptake of colonoscopy, flexible sigmoidoscopy; gFOBT and FIT with diagnostic follow-up
Pancreas	Mortality	Treatment	Develop and evaluate new mutant KRAS inhibitors
Breast	Incidence	Preventive treatment	Evaluate efficacy of low-dose hormone therapies & improve risk-stratification
	Mortality	Modifiable risk factors post-diagnosis	Evaluate strategies for increasing physical activity and decreasing obesity in survivors
		Screening (Early detection)	Increase mammography uptake amongst under-served populations
		Treatment	Increase uptake/adherence to hormone therapy and chemotherapy especially in under-served populations
Prostate	Mortality	Screening (Early detection)	Evaluate risk-stratified PSA screening & improved diagnostic testing
		Treatment	Evaluate strategies to further reduce over treatment and reduce disparities
Liver	Incidence	Modifiable risk factors	Increase uptake of HBV and HCV treatments, decrease smoking prevalence
	Mortality	Screening (Early detection)	Increase cirrhosis diagnosis and screening uptake