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. 2023 May 6;9:147. doi: 10.1038/s41420-023-01453-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A Treatment protocol for subcutaneous xenograft tumors, DU145, and DU145 (B7H3-) in NCG mice. B, C Tumor volume curves of DU145 and DU145(B7H3-) mice treated with PBS (n = 4), control T cells (n = 5), and B7-H3 CAR-T cells (n = 6). The tumor volume data are represented as mean ± SEM (mm³). D, E Body weight curves of the two mouse models. The tumor weight data are represented as mean ± SEM (g). F, G Content of T cells (Figure F) and CAR-T cells (G) in the peripheral blood of mice. H, I Percentage of T cells (H) and CAR-T cells (I) in the spleen. J, K Numbers of T cells (J) and CAR-T cells (K) in tumor tissues. L Immunohistochemical analysis of T cell infiltration in tumor tissue (Scale bar, 20 × 50 μm). All of the results are expressed as the mean of triplicate values ± SEM. **P < 0.01, *P < 0.05 via ANOVA for multiple comparisons of the three treatment groups.