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. Author manuscript; available in PMC: 2023 May 7.
Published in final edited form as: Nat Rev Urol. 2022 Dec 21;20(5):265–278. doi: 10.1038/s41585-022-00686-y

Fig. 2 |. Androgens in prostate homeostasis and regeneration.

Fig. 2 |

Lineage-tracing studies indicate that the regenerative capacity of the prostate gland following withdrawal and re-administration of androgens can be attributed to luminal cells that acquire stem-like transcriptional features and survive castration. Luminal cell survival and regrowth might be determined by microenvironmental niche factors such as fibroblast growth factor (FGF), insulin-like growth factor (IGF), epidermal growth factor (EGF) and hepatocyte growth factor (HGF).