Table 8.

Summary of studies that investigate available prostaglandins and show various effects on corneal endothelium

Prostaglandins	Study	Type of study	Effect
Latanoprost	Honda et al. (2010) [70]	In vivo	Expression of MMP-9 and MMP-1 was increased and TIMP-1 expression was decreased after 8 weeks of latanoprost use in mice
Latanoprost	Lee et al. (2015) [80]	In vivo	Latanoprost significantly reduced CCT in patients with NTG after 5 years of treatment
Latanoprost	Güneş et al. (2021) [11]	In vivo	Latanoprost appeared to reduce CCT at 3-year follow-up, though this 8–10 μm difference in CCT was not clinically significant
Tafluprost	Panos et al. (2013) [81]	In vivo	Decrease of CCT in 93% of eyes treated with tafluprost. CCT reduction was more significant within the first 6 months of the treatment period in patients with glaucoma
Tafluprost	Rossi et al. (2013) [73]	In vivo	No changes of CCT in patients with glaucoma after 12-month treatment

MMP-9 metalloproteinase-9, MMP-1 metalloproteinase-1, CCT central corneal thickness, NTG normal tension glaucoma