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. 2023 Apr 5;29(1-2):25–34. doi: 10.1177/17534259231166212

Figure 1.

Figure 1

SENP3 deficiency in macrophages alleviated LPS-induced acute lung injury and lung inflammation. Notes: Senp3 fl/fl (n = 12) and Senp3 cKO mice (n = 12) were intratracheally injected with LPS (5 mg/kg) for 24 h. (A) Hematoxylin and eosin staining. (B) Lung injury score (n = 6). (C) Wet-to-dry ratio assessment (n = 6). BALF (D) IL-6, (E) TNF-α, (F) IL-10, and (G) IL-4 levels were assessed using ELISA (n = 6). The graphs show the means ± SDs, and data shown in B–G are representative of three independent experiments. Values of p < 0.05 were considered statistically significant, and data marked with a one (*), two (**) and three (***) asterisks indicate p values of <0.05, < 0.01 and <0.001, respectively. SENP3, SUMO-specific peptidase 3; LPS, lipopolysaccharide; BALF, bronchoalveolar lavage fluid; IL, interleukin; TNF-α, tumor necrosis factor α.