Table 1.
Clinical applicability of miR34a bioconjugates in cancer
| MiR-34a Bioconjugate | Targeted Cancer / Type of study |
Results | Ref |
|---|---|---|---|
| miR34a + gold nanoshells |
Breast cancer Triple-negative breast cancer (TNBC) cells In vitro |
↓cancer cell viability ↓proliferation, ↓migration |
[65] |
| MUC1-AgNCm-miR-34a |
Breast cancer MCF-7 cells In vitro |
↓ Bcl-2, ↓Cyclin D1, ↓CDK6 | [66] |
| PEGylated-thymoquinone-nanoparticle-miR-34a |
Breast cancer Human mammary carcinoma cell lines MCF-7, HBL-100 In vitro |
↓cytoskeletal actin polymerization, ↓migration | [67] |
| cRGD-PEG/miR-34a liposomes |
Breast cancer MDA-MB-231 cells In vitro |
↓CD44+/CD24−/low cancer stem cells ↑inhibition of tumor cells, ↓cell proliferation, ↓migration, ↓invasion |
[68] |
| SNALPs- miR-34a- transferrin |
Multiple myeloma In vitro MM cell lines In vivo mouse model with SKMM-1 tumor xenografts |
↓ tumor cell growth ↑survival of mice |
[69] |
| DOX-miR-34a co-loaded HA-CS NPs |
Breast cancer In vitro Triple negative and mesenchymal-type breast cancer cell lines In vivo mice |
↓Bcl-2, ↓migration ↓invasion of breast cancer cells by targeting NOTCH-1 signaling |
[44] |
| miRNA-34a/PLI/HA |
Triple negative breast cancer cell lines In vitro TNBC cells |
↓Bcl-2, ↓cancer cells viability | [70] |
| miR-34a - GD2 antibody-silica NPs |
Pancreatic cancer MIA PaCa-2 cells Panc-1 cell lines In vitro |
↓ tumor cell growth, ↓vascularization ↑TIMP2, ↑apoptosis | [71] |
| EGCG-capped AuNP- miR-34a and let-7a | Hepatocarcinoma cells In vitro | ↓ C-Myc, ↑caspase-3 | [68] |
| miR-34a - poly(lactic-co-glycolic acid) NPs |
Breast cancer In vitro TNBC cells |
↓ cell proliferation, ↓migration, ↓invasion, ↓NOTCH | [69] |
| APA-miRNA–siRNA polyplexe |
Pancreatic cancer In vitro MiaPaCa2 cells |
antitumor effect, ↑ C-Myc | [72] |
| cationic albumin (nanocarrier)- miRNA-34a- docetaxel (DTX) |
Breast cancer In vivo 4T1-tumor bearing mouse model |
↓Bcl-2, ↓cancer cell viability, ↑apoptosis, ↑cytotoxicity | [70] |
| miR34a-volasertib (B16727)-PEG-B-PAEBEA |
Pancreatic cancer in vivo BALB/c nude mice with MIA PaCa-2 xenograft models |
↓ tumor volume, ↑antiproliferative activity, ↓C-Myc | [71] |
| PPP/miR-34a |
Gastric cancer In vitro Human gastric cancer cell lines In vivo mice |
↓proliferation, ↓cell migration, ↓invasion, ↓ NOTCH | [73] |
Abbreviations and symbols: ↑increase, ↓decrease, mucin 1 (MUC1), fluorescent silver nanocluster (AgNC), MicroRNA-34a (miR34a), Cyclic RGD (cRGD)- Polyethylene glycol-modified (PEGylated), Stable nucleic acid lipid vesicles (SNALPs), doxorubicin (DOX) hyaluronic acid (HA)-chitosan (CS), nanoparticles (NPs), chitosan-hyaluronic acid nanoparticles (GCHN), gadoliniu (Gd), Poly-L-Lysine graft imidazole (PLI), Epigallocatechin gallate (EGCG), Gold nanoparticles (AuNPs), poly(ethylene glycol)–poly[aspartamidoethyl(p-boronobenzyl)diethylammonium bromide] (PEG-B-PAEBEA), MM (multiple myeloma)