1+ | High-quality RCTs* and their MA/SR |
1 | Other RCTs and their MA/SR |
2 | Prospective cohort studies, their MA/SR, (predefined) RCT subanalysis |
3 | Non-randomized controlled trials, before-and-after studies, retrospective cohort studies, case-control studies, and their MA/SR and RCT post hoc subanalysis |
4 | Cross-sectional studies, case series |
Consensus | By consensus of the supervisory committee members and the members who prepared the report |
RCT: randomized controlled trial, MA: meta-analysis, SR: systematic review
*A high-quality RCT is defined as (1) large number of subjects, (2) double-blind, independent assessment, (3) high follow-up rate (low dropout rate), (3) low protocol deviation, (4) clear random allocation method, etc.