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Hormone levels were dramatically reduced in Cops5 cKO mice. (A) Testosterone level was decreased in both serum and testis tissue in the Cops5 cKO mice compared with the control group at 66 days old. (B-D) Luteinizing hormone (B), follicle-stimulating hormone (C), and insulin-like growth factor 1 (D) in serum were significantly decreased in Cops5 cKO mice. Statistical significance was evaluated by a 2-tailed unpaired Student's t-test (*P < .05).
