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Impaired skeletal development of Cops5 cKO mice. (A) Representative images showing the variation of the length and width of the tibia between the control and Cops5 cKO mice. Bar = 2 cm (upper panel); bar = 8 mm (lower panel). (B) Immunofluorescence images showing reduced expression of EMCN and COL1 in the tibia of Cops5 cKO mice. (C) Immunofluorescence images showing decreased α-SMA and COL1 in the tissues around the tibia of Cops5 cKO mice. Bar = 1000 μm.
