Table II.
Adjusted1 odds of eosinophilic esophagitis for food allergic registry participants with specific comorbidities
| Comorbidities2 | −EoE n=5765 | +EoE n=309 | Adjusted OR (95% CI) | FDR-adjusted P value |
|---|---|---|---|---|
| Allergic/Immune-Mediated Conditions | ||||
| Allergic rhinitis | 2235 (39%) | 161 (52%) | 1.8 (1.37, 2.22) | 3.9e-05 |
| Asthma | 2603 (45%) | 192 (62%) | 2.0 (1.55, 2.49) | 3.0e-07 |
| Atopic dermatitis | 2751 (48%) | 163 (53%) | 1.3 (0.99, 1.59) | 0.099 |
| Bee sting allergy | 271 (5%) | 17 (6%) | 1.2 (0.68, 1.96) | 0.73 |
| Contact dermatitis | 785 (14%) | 55 (18%) | 1.4 (1.00, 1.84) | 0.092 |
| Drug allergy | 1163 (20%) | 78 (25%) | 1.4 (1.01, 1.81) | 0.09 |
| Food protein-induced enterocolitis syndrome | 85 (1%) | 11 (4%) | 2.5 (1.34, 4.84) | 0.014 |
| Hyper-IgE syndrome | 16 (<1%) | 6 (2%) | 7.6 (2.93, 19.92) | 1.7e-04 |
| Latex allergy | 375 (7%) | 28 (9%) | 1.5 (0.95, 2.21) | 0.12 |
| Mast cell disorder | 61 (1%) | 3 (1%) | 0.91 (0.28, 2.93) | 0.93 |
| Oral allergy syndrome | 582 (10%) | 72 (23%) | 2.8 (2.09, 3.70) | 3.8e-11 |
| Cardiovascular Conditions | ||||
| Arrhythmia | 135 (2%) | 17 (6%) | 2.4 (1.41, 4.14) | 0.0052 |
| Heart defects | 96 (2%) | 6 (2%) | 1.2 (0.51, 2.72) | 0.79 |
| High blood pressure | 305 (5%) | 18 (6%) | 0.99 (0.58, 1.71) | 0.98 |
| Hypertension | 152 (3%) | 10 (3%) | 1.1 (0.57, 2.25) | 0.79 |
| Endocrinologic Conditions | ||||
| Thyroid disease | 291 (5%) | 16 (5%) | 0.98 (0.56, 1.70) | 0.96 |
| Type 2 diabetes mellitus | 90 (2%) | 1 (<1%) | 0.17 (0.02, 1.25) | 0.12 |
| Gastrointestinal Conditions | ||||
| Celiac disease | 139 (2%) | 12 (4%) | 1.6 (0.88, 2.98) | 0.17 |
| Gluten sensitivity | 369 (6%) | 40 (13%) | 2.3 (1.62, 3.36) | 3.9e-05 |
| Heartburn | 1024 (18%) | 129 (42%) | 3.8 (2.92, 4.88) | 9.3e-23 |
| Inflammatory bowel disease | 62 (1%) | 10 (3%) | 3.0 (1.49, 5.88) | 0.0071 |
| Irritable bowel syndrome | 436 (8%) | 29 (9%) | 1.3 (0.83, 1.94) | 0.37 |
| Lactose intolerance | 531 (9%) | 40 (13%) | 1.5 (1.06, 2.17) | 0.053 |
| Neuropsychiatric Conditions | ||||
| Attention deficit hyperactivity Disorder | 427 (7%) | 34 (11%) | 1.5 (1.01, 2.12) | 0.090 |
| Autism | 94 (2%) | 10 (3%) | 1.9 (0.98, 3.71) | 0.099 |
| Migraines | 686 (12%) | 51 (17%) | 1.6 (1.10, 2.19) | 0.030 |
| Oncologic/Rheumatologic/Musculoskeletal Conditions | ||||
| Cancer | 114 (2%) | 3 (1%) | 0.41 (0.13, 1.34) | 0.19 |
| Connective tissue disorder | 72 (1%) | 10 (3%) | 2.6 (1.32, 5.15) | 0.017 |
| Rheumatoid arthritis | 81 (1%) | 6 (2%) | 1.4 (0.58, 3.21) | 0.61 |
| Osteoarthritis | 215 (4%) | 11 (4%) | 0.85 (0.44, 1.64) | 0.75 |
| Other comorbidity | 525 (9%) | 42 (14%) | 1.6 (1.10, 2.17) | 0.030 |
| No comorbidities | 478 (8%) | 1 (<1%) | 0.037 (0.0052, 0.26) | 0.0046 |
CI: confidence interval; EoE: eosinophilic esophagitis; FDR: false discovery rate; OR: odds ratio
1.
Adjusted for sex, age, race, ethnicity, and geographic location in multivariable logistic regression models.
2.
“Histamine toxicity”, “Stroke”, “Heart disease”, and “Type 1 diabetes mellitus” excluded due to <1% of participants reporting these comorbidities in both subsets.