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Nuclear EGFR is required to sustain the activated STAT3 in the nucleus. A. Cell fractions from transfected cells with the indicated EGFR and their mutant plasmids were immunoblotted with the indicated antibodies. B. Working model for canonical and non-canonical EGFR signaling. Ligand-triggered EGFR membrane-bound signaling activates Erk and STAT3, and nuclear EGFR is required for sustaining activated STAT3 via EGFR/STAT3 interaction.
