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. 2023 Apr 15;13(4):1209–1239.

Table 3.

Summary of the characterizations of EGFR

Mutation	Nuclearlocalization	Kinase activity	Migration	TKI resistance	Stemness	Tumorigenic potential	Signaling

							M^a	C^a	N^a
WT	++	++	++	++	++	++	++	++	++
L747A	++++	++++	++++	++++	++++	++++	+++	+++	+++
L747P	++++	++++	++++	++++	++++	++++	+++	+++	+++
L747S	++++	++++	++++	++++	++++	++++	+++	+++	+++
L858R	-	+++	n/a	-	+	+	+++	+++	-
LL1010-1011AA	+/-	++	+	+	+	+	++	-	-
WT-LL1010-1011AA	+/-	++	+	+	+/-	+	++	-	-
L747A-LL1010-1011AA	+	++++	+	+	+/-	+	+++	-	-
L747P-LL1010-1011AA	+	++++	+	+	-	+	+++	-	-
L747S-LL1010-1011AA	+	++++	+	+	-	+	+++	-	-
WT-NLSm	-	+	n/a	n/a	-	+/-	++	++	-
L747P-NLSm	+	++++	n/a	n/a	-	+	+++	+++	-
L747S-NLSm	+	++++	n/a	n/a	-	+	+++	+++	-

^a

M, membrane-bound; C, cytosolic; N, nuclear.