Table 1.
Demographic and PET parameters for the study population
| HC (n=18) | BD-dep (n=17) | BD-euth (n=10) | MDD (n=17) | Statistical test (F or Chi2, p) | |
|---|---|---|---|---|---|
| Age, years (mean±SD) | 36.4±12.8 | 38.9±11.9 | 36.6±13.0 | 33.2±12.1 | 0.605, 0.615 |
| Sex (%female) | 66.7 | 64.7 | 50.0 | 70.6 | 1.231, 0.746 |
| Tobacco users (%) | 22.2 | 23.5 | 50.0 | 29.4 | 2.790, 0.425 |
| MADRS (mean±SD) | 0.7±1.4** | 19.0±6.1†† | 4.6±3.3** | 21.6±6.4†† | 63.395, <0.001 |
| Psychotropic medication (%taking medication) | NA | 23.5 | 30.0 | 26.7 | 0.139, 0.993 |
| Injected tracer dose, MBq (mean±SD) | 155.9±32.0 | 153.0±46.9 | 164.5±24.3 | 167.5±45.3 | 0.485, 0.694 |
| Injected tracer mass, μg (mean±SD) | 0.48±0.26 | 0.34±0.24 | 0.38±0.18 | 0.49±0.65 | 0.835, 0.443 |
| Plasma free fraction, fP (mean±SD) | 0.045±0.01 | 0.048±0.01 | 0.047±0.01 | 0.048±0.01 | 0.210, 0.889 |
| Input function, 90–120 min. SUV (mean±SD) | 0.178±0.03 | 0.166±0.05 | 0.157±0.03 | 0.150±0.04 | ‡1.301, 0.283 |
**
punadj<0.01 vs. MDD
††
punadj<0.01 vs. HC
‡
Main effect of diagnosis, correcting for arterial vs. venous-derived input function