Table 3.
Subgroup analyses of CRC incidences after H. pylori eradication compared with the expected incidence in the matched general population.
| Subgroups | CRC | Colon cancer | Rectal cancer | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Person-years | Observed/expected number of cases | SIR (95% CI) | Person-years | Observed/expected number of cases | SIR (95% CI) | Person-years | Observed/expected number of cases | SIR (95% CI) | |
| Age ⩾60 | 294452.7 | 934/874.0 | 1.09 (0.99–1.15) | 295195.5 | 701/565.4 | 1.24 (1.14–1.35) | 296329.4 | 290/312.5 | 0.93 (0.81–1.06) |
| 1–5 years | 159423.9 | 516/434.7 | 1.19 (1.08–1.31) | 159628.0 | 386/277.4 | 1.39 (1.24–1.56) | 160011.0 | 153/158.4 | 0.97 (0.81–1.16) |
| 6–10 years | 96417.6 | 302/303.3 | 1.00 (0.88–1.13) | 96735.0 | 217/197.5 | 1.10 (0.94–1.28) | 97234.0 | 107/107.5 | 1.00 (0.80–1.24) |
| ⩾11 years | 38611.2 | 116/135.9 | 0.85 (0.69–1.05) | 38832.5 | 98/90.5 | 1.08 (0.86–1.36) | 39084.4 | 30/46.6 | 0.64 (0.43–0.97) |
| Age 40–59 | 497280.6 | 457/479.5 | 0.95 (0.85–1.06) | 497876.9 | 309/276.4 | 1.12 (0.98–1.27) | 498349.6 | 175/204.2 | 0.86 (0.72–1.02) |
| 1–5 years | 235894.7 | 165/167.8 | 0.98 (0.83–1.17) | 236006.0 | 111/93.8 | 1.18 (0.96–1.46) | 236097.4 | 61/74.2 | 0.82 (0.62–1.09) |
| 6–10 years | 173226.1 | 179/182.0 | 0.98 (0.83–1.16) | 173462.4 | 121/105.3 | 1.15 (0.94–1.41) | 173668.6 | 68/77.1 | 0.97 (0.81–1.16) |
| ⩾11 years | 88159.8 | 113/129.7 | 0.87 (0.71–1.08) | 88408.5 | 77/77.3 | 1.00 (0.77–1.28) | 88583.7 | 46/52.9 | 0.87 (0.63–1.21) |
| Age <40 | 146005.2 | 26/24.1 | 1.08 (0.70–1.67) | 146040.8 | 16/12.7 | 1.26 (0.72–2.18) | 146064.0 | 11/11.3 | 0.97 (0.50–1.89) |
| 1–5 years | 65765.8 | 10/6.2 | 1.62 (0.81–3.25) | 65776.3 | 6/3.2 | 1.87 (0.77–4.53) | 65775.2 | 5/3.0 | 1.69 (0.64–4.43) |
| 6–10 years | 50972.5 | 11/8.7 | 1.26 (0.65–2.45) | 50984.8 | 7/4.6 | 1.52 (0.67–3.46) | 50996.1 | 4/4.1 | 0.97 (0.33–2.84) |
| ⩾11 years | 29267.0 | 5/9.2 | 0.55 (0.21–1.43) | 29279.7 | 3/4.9 | 0.61 (0.18–2.06) | 29292.7 | 2/4.3 | 0.47 (0.11–2.01) |
| Retreatment | 95437.9 | 152 / 127.2 | 1.20 (1.00–1.43) | 95611.0 | 110 / 78.6 | 1.40 (1.13–1.73) | 95736.5 | 54 / 49.1 | 1.10 (0.81–1.49) |
| 1–5 years | 47312.9 | 70/55.8 | 1.25 (0.96–1.64) | 47351.5 | 45/34.1 | 1.32 (0.95–1.84) | 47375.7 | 28/21.8 | 1.29 (0.84–1.96) |
| 6–10 years | 32578.8 | 53/46.1 | 1.15 (0.85–1.56) | 32656.7 | 41/28.6 | 1.43 (1.01–2.03) | 32710.3 | 17/17.7 | 0.96 (0.56–1.64) |
| ⩾11 years | 15546.2 | 29/25.3 | 1.15 (0.76–1.74) | 15602.8 | 24/15.8 | 1.52 (0.96–2.39) | 15650.4 | 9/9.6 | 0.94 (0.45–1.95) |
| Eradication success | 842300.6 | 1265/1250.4 | 1.01 (0.95–1.08) | 843502.2 | 916/776.0 | 1.18 (1.10–1.27) | 845006.4 | 422/478.9 | 0.88 (0.79–0.98) |
| 1–5 years | 413771.5 | 621/552.9 | 1.12 (1.03–1.23) | 414058.7 | 458/340.3 | 1.35 (1.21–1.49) | 414507.8 | 191/213.7 | 0.89 (0.76–1.05) |
| 6–10 years | 288037.4 | 439/447.9 | 0.98 (0.88–1.09) | 288525.6 | 304/278.8 | 1.09 (0.96–1.24) | 289188.3 | 162/171.0 | 0.95 (0.79–1.13) |
| ⩾11 years | 140491.7 | 205/249.6 | 0.82 (0.70–0.96) | 140917.9 | 154/156.9 | 0.98 (0.82–1.18) | 141310.4 | 69/94.2 | 0.73 (0.56–0.96) |
| Prior lower endoscopy a | 115713.0 | 130/200.0 | 0.65 (0.53–0.79) | 115840.4 | 90/124.7 | 0.72 (0.57–0.91) | 115977.8 | 45/75.8 | 0.59 (0.43–0.83) |
| 1–5 years | 62404.1 | 75/98.7 | 0.76 (0.59–0.98) | 62443.9 | 50/61.0 | 0.82 (0.60–1.12) | 62498.9 | 27/37.9 | 0.71 (0.46–1.09) |
| 6–10 years | 38659.7 | 40/71.1 | 0.56 (0.40–0.80) | 38710.8 | 29/44.6 | 0.65 (0.43–0.98) | 38774.3 | 13/26.7 | 0.49 (0.26–0.90) |
| ⩾11 years | 14649.1 | 15/30.2 | 0.50 (0.28–0.88) | 14685.7 | 11/19.2 | 0.57 (0.30–1.11) | 14704.6 | 5/11.2 | 0.45 (0.17–1.18) |
| No prior lower endoscopy | 822025.6 | 1287/1177.5 | 1.09 (1.03–1.16) | 823272.8 | 936/729.9 | 1.28 (1.19–1.38) | 824765.1 | 431/452.2 | 0.95 (0.86–1.06) |
| 1–5 years | 398680.3 | 616/510.0 | 1.21 (1.10–1.32) | 398966.3 | 453/313.4 | 1.45 (1.30–1.61) | 399384.6 | 192/197.6 | 0.97 (0.83 1.14) |
| 6–10 years | 281956.5 | 452/422.9 | 1.07 (0.96–1.19) | 282471.5 | 316/262.9 | 1.20 (1.06–1.36) | 283124.3 | 166/162.0 | 1.02 (0.86–1.22) |
| ⩾11 years | 141388.8 | 219/244.6 | 0.90 (0.77–1.04) | 141835.0 | 167/153.6 | 1.09 (0.91–1.29) | 142256.2 | 73/92.6 | 0.79 (0.61–1.02) |
a
Including any colonoscopy, sigmoidoscopy, or polypectomy before the primary eradication.
CI, confidence interval; CRC, colorectal cancer; SIR, standardized incidence ratio.