Table 4.

Predictors of OAC use (high-risk group).

Variables	OAC use (vs no OAC)		DOAC use (vs warfarin)
	OR (95% CI)	p value	OR (95% CI)	p value
Age group
18–64 years	ref	ref	ref	ref
65–74 years	1.41 (1.37, 1.46)	<0.0001	1.06 (1.00, 1.11)	0.0436
75 + years	1.51 (1.46, 1.56)	<0.0001	0.85 (0.81, 0.90)	<0.0001
Gender
Female	ref	ref	ref	ref
Male	1.03 (1.01, 1.04)	0.0006	0.81 (0.79, 0.83)	<0.0001
Health plan
Commercial	ref	ref	ref	ref
Medicare Advantage	0.91 (0.89, 0.94)	<0.0001	0.47 (0.44, 0.49)	<0.0001
CHA2DS2-VASc components
Heart failure	1.02 (1.00, 1.04)	0.0184	0.62 (0.60, 0.63)	<0.0001
Diabetes mellitus	1.07 (1.05, 1.08)	<0.0001	0.92 (0.90, 0.94)	<0.0001
Thromboembolism	1.07 (1.04, 1.10)	<0.0001	0.88 (0.84, 0.92)	<0.0001
CAD or PAD	0.87 (0.85, 0.88)	<0.0001	0.84 (0.82, 0.86)	<0.0001
HAS-BLED components
CKD	0.89 (0.87, 0.91)	<0.0001	0.96 (0.93, 0.98)	0.0015
Stroke	1.03 (1.00, 1.07)	0.0557	0.90 (0.85, 0.94)	<0.0001
Anemia/Major bleed	0.83 (0.82, 0.85)	<0.0001	0.86 (0.84, 0.88)	<0.0001
Liver disease	0.88 (0.86, 0.90)	<0.0001	1.21 (1.17, 1.25)	<0.0001
Alcoholism	0.82 (0.79, 0.84)	<0.0001	1.21 (1.14, 1.28)	<0.0001
Antiplatelets/NSAIDs	0.75 (0.74, 0.77)	<0.0001	1.86 (1.80, 1.93)	<0.0001
Other comorbidities
Falls	0.74 (0.73, 0.75)	<0.0001	1.02 (0.99, 1.05)	0.2745
Obesity	1.32 (1.30, 1.34)	<0.0001	1.26 (1.23, 1.29)	<0.0001
Intervention
Catheter ablation/surgical ablation/MAZE	0.89 (0.84, 0.95)	0.0005	1.03 (0.95, 1.12)	0.5133
Cardioversion	2.14 (2.07, 2.22)	<0.0001	0.92 (0.88, 0.96)	0.0001
Implanted device	1.18 (1.15, 1.20)	<0.0001	0.72 (0.69, 0.74)	<0.0001
Concurrent medication
Amiodarone/other AADs	1.04 (1.02, 1.06)	0.0006	0.67 (0.64, 0.69)	<0.0001

Multivariable model assessing the association of clinically relevant variables to oral anticoagulant use within the high-risk group.

Abbreviations: coronary artery disease (CAD); peripheral artery disease (PAD); chronic kidney disease (CKD); antiarrhythmic drug (AAD).